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HISTORY OF BEE VENOM THERAPY

Perhaps the most exotic product from the hive is bee venom. Bee venom has been used via bee-sting therapy for centuries in many cultures. Hippocrates and Confucius were familiar with its healing properties.


Eastern countries in particular have employed the curative abilities of bee venom, in fact, large clinics dedicated entirely to bee venom therapy are common in China. Its popularity is rapidly increasing in Europe and North America for the purposes of providing relief to arthritis sufferers and desensitizing those that are allergic to bee stings.

In a movement towards healthier lifestyles and in the reaction to the dangers of modern drugs and their side effects, people are now turning to more natural ways of treating their conditions. Thus the use of bee products are, once again, gaining popularity. The American Apitherapy Society is just one body that has been formed to promote the use of the bee venom therapy. In the past the only way to receive bee venom therapy was through an injection or the actual bee sting. Now with new technology produced by Nelson Apiaries, bee venom therapy can be administered in a much sweeter, less painful way.

HISTORY OF Nectar Ease™ AND NELSON APIARIES

Nectar Ease™ is the Original Manuka honey with bee venom.

Things are buzzing for Nelson Apiaries Ltd., operated by the Cropp family who have been working bees for the past 100 years. The noise maker is a revolutionary new product called Nectar Ease™, the result of a mistake made in Phillip Crops honey shed in 1996. Little did he imagine the impact his error would create worldwide in the field of natural health.

Nectar Ease™ is bee venom mixed with Manuka honey and the process of mixing the two is a world first.

The therapeutic benefits of bee venom have been known for years - bee sting therapy being used for arthritis is recorded as far back as Hippocrates and Galen in 130AD.
The treatment still has widespread support in many European countries and China in spite of the unpleasantness of a course of bee stings.
Phillip Cropp was familiar with bee sting therapy, but it was not until something extraordinary occurred to a friend who ate his honey that he really focused on the matter. Philip tells the story:
"About three years ago, a bloke up the road came in for some honey, which we gave to him. Two days later he was back for more because he reckoned the arthritis in his hands was healing up. I thought he was having me on. The man was delighted that he no longer had to limber up his hands before holding his breakfast utensils each morning. He was sure it was the honey, but it had come from a pail which wasn't anything special." Or so Phil thought until he investigated and discovered the honey was different. It had had bee venom with it by mistake. "I wasn't trying to invent anything. It was just something I did. I knew what had happened but I forgot about it when I gave the honey away." The discovery led Phil to collect all the information he could find about bee sting therapy and it's reputed abilities to help arthritis, multiple sclerosis and a number of other problems. Years passed before local demand grew and Phil then began selling direct to the public under the brand name thought typical of the benefits -
Nectar Ease™ - sweet taste and relief.

ADDITIONAL HEALTH BENEFITS

In addition to arthritis there are also reports of bee venom therapy assisting in the control of:

  • Auto-Immune Disease
  • Amyloid Neuropathy
  • Multiple Sclerosis
  • Lupis Erythemematosis
  • Scleroderma
  • Fibrositis
  • Mastitis
  • Ankylosing Spondylitis
  • Shingles
  • Gout
  • Tennis Elbow
  • Tendonitis
  • Bursitis
  • Lower-back Pain
  • Chronic Pain
  • Ligament Injuries
  • Premenstrual Syndrome
  • Cholesterol Levels
  • Neurosis
Nectar Ease™ AND YOUR BEST FRIENDS

People often use alternative therapies for themselves but seldom consider their application for their pets, even their working animals. However, Nectar Ease™ is also used by many customers to treat their animals, including dogs, cats and horses. Normal guidelines to dosage are applied.


SCIENCE OF BEE VENOM THERAPY

Clinical Trial Results on Nectar Ease™, November 2000

An early clinical trial on 20 arthritis patients conducted in Auckland found that 66% of patients experienced a reduction in their pain levels when treated by
Nectar Ease™. Encouraged by these results, Nelson Apiaries went on to conduct a full double blind trial in Hamilton under Dr Alan Dobe, Rheumatologist. Just completed, this trial showed statistically significant improvements in the level of pain for the osteo arthritis patients and in mobility for both osteo and rheumotoid arthritis patients.

An improvement in pain was observed in 66% of osteo arthritis patients treated with
Nectar Ease™.

In both trials patients remained on their regular therapies which included non-steroidal anti-inflammatories (Voltaren etc), aspirin and paracetamol.

These trials confirm what our customers have been telling us for years - that our unique mix of bee venom and our special brand of manuka honey helps reduce the pain of arthritis.

Bee Venom Components

The actual healing process is still a bit of a mystery but ongoing research has identified a number of naturally occurring chemical compounds, which appear to work together in the body. One possible way that bee venom works its anti-inflammatory effects is by assisting the production of cortisoles in the human body. This is compared to synthetic cortisone with out the side effects. Bee venom has anti-oxidant qualities, which make it effective as a booster for the natural immune system.

Research has so far established that Bee Venom Therapy stimulates the activity of the immune system so the body produces it's own healing agents

Like many alternative and folk remedies there seems little evidence to suggest a mechanism by which bees venom could have any therapeutic value. However, there have been studies performed which have demonstrated the existence of compounds in bees venom with important and very relevant pharmacological properties. Amongst the most important of these seems to be Peptide-401, commonly referred to as the mast cell degranulating peptide of MCD for short. Researchers from Guys Hospital and the Kennedy Institute of Rheumatology published a report in 1973 about Peptide-401 in which they demonstrated it to be 100 times more effective as an anti-inflammatory agent than hydro cortisone. However, another compound that has come under great scrutiny is Mellitin which forms the bulk of dried bees venom. Many studies have been performed around the world investigating its properties one of which demonstrated it to inhibit the formation of free radicals which are believed to contribute to joint damage. Mellitin has also been shown to indirectly stimulate the adrenal gland to produce the bodies own cortisol by stimulating the pituitary gland to release ACTH.

"Bee Venom Therapy is a classic example of the homeopathic principal, which states that a substance that produces the symptoms of a disease is a cure for that disease. Rheumatic diseases result in swelling, pain and inflammation. A bee sting causes the same symptoms. The sting stimulates the immune system to relive the inflammation caused by the bee venom, while relieving the symptoms of the rheumatic disease at the same time. Bee Venom Therapy stimulates the immune system through the hypothalamus, pituitary and adrenal glands. This therapeutic effect stimulates the immune system rather than suppressing it, completely contrary to the effects of many drugs. "¹

¹Chrles Mraz, Health and the Honeybee, p. 46; Queen City Publications, 1995

Bees venom contains a compound called apamin which enhances long term synaptic transmission and dopamine which helps increase motor activity. The implications of their actions are obvious although not proven in any studies. In addition there is a component of bees venom called adolapin, also a neurotransmitter, that has been shown to have an analgesic effect which may be important for those who suffer pain as one of the symptoms.

Nectar Ease™ Honey is a creamed blend of Manuka honey and other honey, with Manuka constituting between 60-65% of the raw material before processing. The bee venom component is considered to be the active compound in the product. The venom composition and strength varies between honeybee species and small variances are even identifiable inter-specifically between races and locations. The bee venom used in the Nectar Ease™ product is extracted exclusively from the Apis Melifera species of honeybee.

The following table expresses the composition of venom from a honeybee worker as stated in the findings of two separate studies (Dotimas and Hilder, 1987 (1); Shipolini, 1984 (2)).
Hilder, 1987 (1); Shipolini, 1984 (2)). These components were measured as a percentage of dry venom, with water makes up approximately 88% of venom before drying.
Class of Molecules Component % of Dry Venom (1) % of Dry Venom (2)

Class of Molecules Component % of Dry Venom (1) % of Dry Venom (2)
Enzymes Phospolipase A2 10-12 10-12
  Hyaluronidase 1-3 1.5-2.0
  Acid phosphomonoesterase   1.0
  Lysophopholipase   1.0
  a -glucosidase   0.6
Other Proteins and Melittin 50 40-50
Peptides Apamine 1-3 3
  Mast Cell Degranulating Peptide (MCD) 1-2 2.0
  Secapin 0.5-2.0 0.5
  Procamine 1-2 1.4
  Adolapin   1.0
  Protease inhibitor   0.8
  Tertiapin * 0.1 0.1
  Small peptides (with less than 5 amino acids) 13-15  
Physiologically Active Histamine 0.5-2.0 0.6-1.6
Amines Dopamine 0.2-1.0 0.13-1.0
  Noradrenaline 0.1-0.5 0.1-0.7
Amino Acids t -aminobutyric acid 0.5 0.4
  a -amino acids 1.0  
Sugars Glucose and fructose 2  
Phospholipids   5  
Volatile compounds   4-8  

In 1982 Bulgarian researchers Shkendrov and Koburova isolated another peptide in bee venom called adolapin and showed that it had anti-inflammatory and analgesic properties.

In April 1993 Chen, Chen and Sun of the Nanjing Institute of Biochemical Pharmacy in China not only noted the anti-inflammatory properties of bee venom but also demonstrated its analgesic effects.

In July 1990 Ziai, Russek, Wang, Beer, Blume from the American Cyanamid Company, Pearl River, New York, USA commented that peptide-401 displays striking immunological and pharmacological activities. They also demonstrated that MCD significantly lowered blood pressure in rats.

Glucosamine
Added to
Nectar Ease™ Plus - Honey and Capsules

In the case of Asthma, Eczema, Arthritis and Crohn's Disease the body uses the immune system to cause inflammation which produces Glucuronic Acid and Glucosamine to eliminate the toxins which have entered the body through our eating, drinking and breathing habits. It is a naturally formed substance but in the above cases the body cannot produce enough to fight the imbalance and it is necessary to take some Glucosamine to supplement the body's natural performance.

All available research prove that Glucosamine Sulfate is effective in treating Osteoarthritis. Fifteen years ago, researchers began supplementing Glucosamine Sulfate to Degenerative Joint Disease (Osteoarthritis) patients. This naturally occurring molecule is used by the body to make cartilage in healthy joints. Researchers hoped that supplying this building block might lead to repair of degenerative joint disease damaged joints. Subsequently, double blind trials have consistently shown Glucosamine Sulfate is effective. In one double blinded trial the standard dose of Glucosamine Sulfate (500 mg taken three times per day) led to a 40% drop in pain. All ten patients who received Glucosamine Sulfate in the trial had a reduction in joint swelling, and eight of the ten suffered less pain. Two other blinded trials also reported greater pain relief in the Glucosamine treated groups. Another double blinded trial reported a sharper (73%) drop in symptoms for those taking Glucosamine.

Benefits and Features include the following:
· It is a key component in synovial, bursa fluid, and loose connective tissues.
· It is required by the tendons and ligaments and is rich in chrondritins.
· It is a component of the gel-like matrix between collagen fibers.
· It helps support the immune system and is a component of some enzymes.
· It is a component of mucous membranes lining the digestive, respiratory and urinary tracts.
· It encourages growth of beneficial bacteria in the gut.
· It is a key component of chitin, the tough material found in the nails.


Links to Information on Bee Venom Therapy

Technology New Zealand Media Release:
Information regarding the outcome of this study will be added to Honeybee Therapy's Web Site after the study results are released.

The Internet Health Library 2000, "Therapies Bee Venom Therapy"
· "What is Bee Venom
· What does Bee Venom contain?
· How does it work?
· What type of conditions is Bee venom used to treat?
· Research and methods of using Bee venom"

The Internet Health Library 2000, "Therapies Bee Venom Research"

MS Association of King County/Bee Sting Therapy

"Bee Venom Protocol for Lyme's Disease 7/23/00"

Bee Venom Frequently Asked Questions

 


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